Scientific Name: Panthera tigris altaica
Taxonomy: Cellular organisms-> Eukaryota-> Opisthokonta-> Metazoa-> Eumetazoa-> Bilateria-> Deuterostomia-> Chordata-> Craniata-> Vertebrata-> Gnathostomata-> Teleostomi-> Euteleostomi-> Sarcopterygii-> Dipnotetrapodomorpha-> Tetrapoda-> Amniota-> Mammalia-> Theria-> Eutheria-> Boreoeutheria-> Laurasiatheria-> Carnivora-> Feliformia-> Felidae-> Pantherinae-> Panthera-> Panthera tigris
Summary: The DPP4 gene encodes dipeptidyl peptidase 4, which is identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. It is an intrinsic type II transmembrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. Dipeptidyl peptidase 4 is highly involved in glucose and insulin metabolism, as well as in immune regulation. This protein was shown to be a functional receptor for Middle East respiratory syndrome coronavirus (MERS-CoV), and protein modeling suggests that it may play a similar role with SARS-CoV-2, the virus responsible for COVID-19. [provided by RefSeq, Apr 2020] [NCBI] [Proteinatlas]
Data set information
| Project | Date | Technology | Tissue | Condition | Cell | PMID/DOI |
|---|---|---|---|---|---|---|
| Vthunter_0023 | 2021.04 | 10X Genomics | Heart | Normal | 16479 | Link |
| Vthunter_0024 | 2021.04 | 10X Genomics | Kidney | Normal | 3483 | Link |
| Vthunter_0025 | 2021.04 | 10X Genomics | Liver | Normal | 10237 | Link |
| Vthunter_0026 | 2021.04 | 10X Genomics | Lung | Normal | 14159 | Link |
| Vthunter_0027 | 2021.04 | 10X Genomics | Spleen | Normal | 33029 | Link |
| Vthunter_0057 | 2021.04 | iDrop | PBMC | Normal | 4755 | Link |
Featureplot of receptors
Expression: Biased expression in small intestine (RPKM 70.7), placenta (RPKM 57.1) and 13 other tissues
